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Invitrogen
Ghrelin Monoclonal Antibody (121)
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产品信息
ABS 052-121-02
产品规格
种属反应
Dog,
Cat,
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
121
抗原
Synthetic ghrelin (14-28).
偶联物
形式
Liquid
浓度
0.9 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: ABS 052-121-02 cross-reacts with rat ghrelin, and is predicted to react with mouse, dog and cat based on sequence homology.
Reactivity: ABS 052-121-02 binds human ghrelin in solution. ABS 052-121-02 can be used as a detection antibody in a sandwich ELISA with capture antibody ABS 050-45-02.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
靶标信息
GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an the ligand for the growth hormone secretagogue receptor type 1 and is involved in regulating growth hormone release. Ghrelin has an appeptite-stimulating effect and induces adiposity and stimulates gastric acid secretion. Obestatin may be the ligand for the orphan G protein-coupled receptor GPR39 and is involved in satiety and can have an appetite-reducing effect resulting in decreased food intake.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AMCBX1; Appetite-regulating hormone; FIP-3; FIP3; Fip3p; ghrelin; ghrelin 27; ghrelin 28; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin; ghrelin/obestatin preprohormone; Growth hormone secretagogue; Growth hormone-releasing peptide; IKK-gamma; In2c-preproghrelin; IP; IP1; IP2; IPD2; motilin related peptide; Motilin-related peptide; NEMO; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; prepro-appetite regulatory hormone; preproghrelin; proghrelin; Protein M46
基因别名: 2210006E23Rik; Ghr; GHRL; m46; MTLRP; MTLRP-AP; MTLRPAP; UNQ524/PRO1066
UniProt ID: (Human) Q9UBU3, (Dog) Q9BEF8, (Cat) Q6BEG6, (Rat) Q9QYH7, (Mouse) Q9EQX0
Entrez Gene ID: (Human) 51738, (Dog) 403587, (Cat) 493844, (Rat) 59301, (Mouse) 58991
activation of MAPK activity
gastric acid secretion
negative regulation of endothelial cell proliferation
glucose metabolic process
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
actin polymerization or depolymerization
adult feeding behavior
response to hormone
hormone-mediated signaling pathway
dendrite development
negative regulation of angiogenesis
growth hormone secretion
positive regulation of insulin secretion
regulation of response to food
positive regulation of appetite
negative regulation of interleukin-1 beta production
negative regulation of locomotion
positive regulation of multicellular organism growth
regulation of cell proliferation
negative regulation of circadian sleep/wake cycle, REM sleep
negative regulation of tumor necrosis factor biosynthetic process
negative regulation of apoptotic process
cortisol secretion
response to estrogen
negative regulation of interleukin-6 biosynthetic process
positive regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of insulin secretion
decidualization
negative regulation of inflammatory response
cartilage development
positive regulation of corticotropin secretion
positive regulation of cortisol secretion
positive regulation of synapse assembly
excitatory postsynaptic potential
positive regulation of growth hormone secretion
positive regulation of growth hormone receptor signaling pathway
positive regulation of protein tyrosine kinase activity
negative regulation of energy homeostasis
positive regulation of energy homeostasis
positive regulation of response to food
negative regulation of interleukin-6 production
positive regulation of cold-induced thermogenesis
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